Cultured Lentinula edodes Mycelia Extract

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable capsule-based formulation of a standardized extract of cultured Lentinula edodes (Shiitake mushroom) mycelia (ECLM), which is high in the polysaccharides beta- and alpha-glucans, with potential antioxidant, immunomodulating and antineoplastic activities. Upon oral administration, the cultured Lentinula edodes mycelia extract activates the immune system, by binding to toll-like receptors (TLRs), specifically TLR-4, and induces the activation of dendritic cells (DCs), natural killer (NK) cells, macrophages and T-cells and the release of cytokines. This may clear human papillomavirus (HPV) infections.

**Synonyms:** - ACTIVE HEXOSE CORRELATED COMPOUND - AHCC - Cultured Lentinula edodes Mycelia Extract AHCC - ECLM - L. edodes Mycelia Extract AHCC - Lentinula edodes Mycelia Extract - Standardized Extract of Cultured Lentinula edodes Mycelia - Yinuojin Ruanjiaonang