Autologous Anti-ALPP CAR Retroviral Vector-transduced T Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting alkaline phosphatase, placental type (ALPP; placental alkaline phosphatase; PLAP), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-ALPP CAR retroviral vector-transduced T cells target and bind to ALPP-expressing tumor cells, thereby inducing selective toxicity in ALPP-expressing tumor cells. ALPP, mainly expressed in placenta and testis, is overexpressed on certain tumor cell types, such as on a proportion of colorectal cancers while not expressed in any other normal tissues. It plays a key role in tumor cell proliferation.

**Synonyms:** - Anti-ALPP CAR-expressing Retroviral Vector-transduced Autologous T Cells - Autologous Anti-ALPP CAR-modified T-cells - Autologous Anti-ALPP CART-cells - Retroviral Vector-transduced Anti-PLAP CAR Autologous T-cells