(R)-2-Hydroxyglutarate

**Semantic type:** Organic Chemical

**Definition:** The R-enantiomer of alpha-hydroxyglutarate (2-HG) where the hydroxy group is attached to the right side of the asymmetric carbon furthest from the carbonyl. This isoform is the predominant form found in gliomas associated with the expression of isocitrate dehydrogenase (IDH) mutants. Therefore, measurement of the expression of the R-form may be correlated more closely with those diseases than measurement of total 2-HG.

**Synonyms:** - (2R)-2-Hydroxypentanedioic Acid - (R)-2-Hydroxyglutaric Acid - (R)-2HG - (R)-Hydroxyglutarate - D-2-HG - D-2-Hydroxyglutarate - D-2-Hydroxyglutarate - D-2HG - D2HG