Inactivating CHEK1 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the CHEK1 gene that either inhibits expression or results in the translation of an inactive serine/threonine-protein kinase Chk1 protein.

**Synonyms:** - CHEK1 Gene Inactivation - CHEK1 Inactivating Gene Mutation - CHEK1 Inactivating Mutation - CHEK1 Loss of Function Gene Mutation - CHEK1 Loss of Function Mutation - Inactivating CHEK1 Mutation - Inactivating CHK1 Gene Mutation - Inactivating Checkpoint Kinase 1 Gene Mutation