Inactivating CHEK2 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the CHEK2 gene that either inhibits expression or results in the translation of an inactive serine/threonine-protein kinase Chk2 protein.

**Synonyms:** - CHEK2 Gene Inactivation - CHEK2 Inactivating Gene Mutation - CHEK2 Inactivating Mutation - CHEK2 Loss of Function Gene Mutation - CHEK2 Loss of Function Mutation - Inactivating CDS1 Gene Mutation - Inactivating CHEK2 Mutation - Inactivating CHK2 Gene Mutation - Inactivating Checkpoint Kinase 2 Gene Mutation - Inactivating LFS2 Gene Mutation - Inactivating RAD53 Gene Mutation - Inactivating hCds1 Gene Mutation