Activating LGR5 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the LGR5 gene that results in constitutive activation of both leucine-rich repeat-containing G-protein coupled receptor 5 and its downstream signaling pathways.

**Synonyms:** - Activating FEX Gene Mutation - Activating GPR49 Gene Mutation - Activating GPR67 Gene Mutation - Activating GRP49 Gene Mutation - Activating HG38 Gene Mutation - Activating LGR5 Mutation - Activating Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 Gene Mutation - Gain of Function LGR5 Gene Mutation - Gain of Function LGR5 Mutation - LGR5 Activating Gene Mutation - LGR5 Activating Mutation - LGR5 Gain of Function Gene Mutation - LGR5 Gain of Function Mutation