TLR1/2 Agonist Pam3Cys-GDPKHPKSF

**Semantic type:** Pharmacologic Substance

**Definition:** A vaccine adjuvant and synthetic Toll-like receptor (TLR) type 1 and 2 ligand composed of a lipopeptide containing a water-soluble derivative of Pam3-Cys, the biologically active component of the mycobacterial 19 kDa lipoprotein of mycobacteria, that is covalently linked to a synthetic peptide (GDPKHPKSF), with potential immunostimulating activity. Upon administration, TLR1/2 agonist Pam3Cys-GDPKHPKSF targets, binds to and activates TLR1/2, which induces CD8- and T-helper 1 CD4-positive T-cell responses. This may enhance T-cell-mediated immune responses when administered together with peptide vaccine.

**Synonyms:** - N-Palmitoyl-S-[2,3-bis(palmitoyloxy)-(2R)-propyl]-(R)-cysteinyl-GDPKHPKSF - Pam3Cys-GDPKHPKSF XS15 - TLR1/2 Agonist XS15 - TLR1/2 Ligand XS15 - XS 15 - XS-15 - XS15