Anti-TNFR2 Monoclonal Antibody BI-1808

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A human immunoglobulin G1 (IgG1) monoclonal antibody directed against tumor necrosis factor Receptor 2 (TNFR2; tumor necrosis factor receptor superfamily member 1B; TNFRSF1B), with potential antineoplastic activity. Upon administration, anti-TNFR2 monoclonal antibody BI-1808 targets and binds to TNFR2 on tumor-associated regulatory T cells (Tregs) in the tumor microenvironment (TME), thereby preventing TNFR2-mediated signaling. This depletes intra-tumoral Tregs, induces and expands intra-tumoral CD8+ T-cells, thereby enhancing T-cell-mediated immune responses against tumor cells. TNFR2 plays a role in tumor necrosis factor signaling, tumor expansion and survival.

**Synonyms:** - BI 1808 - BI-1808 - BI1808