Ribocytokine IL-7 BNT152

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A formulation consisting of lipid nanoparticles (LNPs) encapsulating nucleoside-modified messenger RNA (mRNA) encoding the endogenous cytokine interleukin-7 (IL-7), with potential immunostimulating activity. Upon administration, ribocytokine IL-7 BNT152 is taken up by cells and the expressed IL-7 targets and binds to the IL-7 receptor (IL7R). The binding of IL-7 to IL7R activates IL7/IL7R-mediated signaling, which activates B- and T- lymphocytes, may improve immune recovery and activation, and may enhance anti-tumor immune responses.

**Synonyms:** - BNT 152 - BNT-152 - BNT-152 MRNA - BNT152 - Human Interleukin-7 mRNA-encoded BNT152