Shark Cartilage Extract AE-941

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.

**Synonyms:** - AE-941 - AE-941 - Neovastat - Neovastat - [AElig]-941