TMPRSS6 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TMPRSS6 wild-type allele is located in the vicinity of 22q12.3 and is approximately 45 kb in length. This allele, which encodes transmembrane protease serine 6 protein, plays a role in processing hemojuvelin, type I collagen, fibronectin and fibrinogen. Mutation of the gene is associated with iron-refractory iron deficiency anemia.

**Synonyms:** - FLJ30744 - IRIDA - MT2 - Transmembrane Protease, Serine 6 Gene - Transmembrane Serine Protease 6 wt Allele - UNQ354/PRO618