Cell-Mediated Immunity Multitest

**Semantic type:** Laboratory Procedure

**Definition:** Multitest CMI is a diagnostic technique for detection of anergy (nonresponsiveness to antigens) by means of delayed hypersensitivity skin testing. This test uses seven antigens: tuberculin, tetanus, diphtheria, Streptococcus, Candida, Trichophyton, and Proteus to test for cutaneous delayed-type hypersensitivity responses in humans. The test is administered by pressing the antigen heads of the Multitest applicator firmly onto the volar surface of the lower arm. A positive reaction to an antigen is manifest as an inflammatory response at the site of administration.