Etaracizumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin. Etaracizumab blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types.

**Synonyms:** - Abegrin - Abegrin - ETARACIZUMAB - Humanized Monoclonal Antibody LM609 - MEDI-522 - MEDI-522 - Monoclonal Antibody Anti-Avb3 Integrin Medi-522 - Monoclonal Antibody Anti-alpha V Beta 3 Integrin MEDI-522 - Vitaxin - etaracizumab - humanized monoclonal antibody MEDI-522