Bcl-2 Inhibitor ABBV-623

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, Bcl-2 inhibitor ABBV-623 targets, binds to and inhibits the activity of Bcl-2. This restores caspase-mediated apoptosis in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis. Its expression is associated with increased drug resistance and tumor cell survival.

**Synonyms:** - ABBV 623 - ABBV-623 - ABBV623 - BCL2 Inhibitor ABBV-623