Polycomb Repressive Complex 2

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A protein complex that represses transcription by stimulating chromatin compaction through the trimethylation of lysine-27 of histone H3, which recruits Polycomb repressive complex 1. This complex is involved in embryonic development, X chromosome inactivation, maintenance of stem cell fate and imprinting.

**Synonyms:** - PRC2