TGF-beta2 Antisense Oligonucleotide TASO-001

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A transforming growth factor (TGF)-beta2 specific antisense oligodeoxynucleotide (ASO), with potential antineoplastic activity. Upon administration, TGF-beta2 ASO TASO-001 binds to TGF-beta2 mRNA causing inhibition of protein translation. This decreases TGF-beta2 levels, which may result in the inhibition of tumor cell growth and migration, and tumor angiogenesis. TGF-beta2, a cytokine overexpressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells.

**Synonyms:** - TASO 001 - TASO-001 - TASO001 - TGF-beta2 ASO TASO-001 - TGF-beta2-targeting Antisense Oligonucleotide TASO-001