Base Editing

**Semantic type:** Molecular Biology Research Technique

**Definition:** A technique for the direct conversion of a specific DNA base into another at a targeted genomic locus. This technique uses a Cas nickase, or Cas fused to a deaminase, that makes the edit and a guide RNA that targets Cas to a specific locus. Cytosine base editors mediate a C to T change and adenine base editors mediate an A to G change.

**Synonyms:** - Base Editor