Transcription Activator-like Effector Nuclease

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** A class of custom, sequence-specific DNA endonucleases created by fusing an engineered transcription activator-like effector protein to the catalytic cleavage domain of the FokI restriction enzyme.

**Synonyms:** - TAL Nuclease - TALE Nuclease - TALEN - TALEN