Anbalcabtagene Autoleucel

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anbalcabtagene autoleucel targets and binds to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell lysis. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors.

**Synonyms:** - ANBALCABTAGENE AUTOLEUCEL - Autologous Anti-CD19 CAR T Cells CRC01 - Autologous Anti-CD19 CAR-T Cells CRC01 - CRC 01 - CRC-01 - CRC01