Becotatug Vedotin

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC) consisting of becotatug, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the epidermal growth factor receptor (EGFR) conjugated to monomethyl auristatin E (MMAE), an auristatin derivative and potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration of becotatug vedotin, the monoclonal antibody moiety binds to EGFR on tumor cell surfaces. Following receptor internalization, the MMAE moiety is released and binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and apoptosis. This inhibits the proliferation of EGFR-expressing tumor cells. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival.

**Synonyms:** - Anti-EGFR ADC MRG003 - Anti-EGFR Antibody-drug Conjugate MRG003 - Anti-EGFR/MMAE Antibody-drug Conjugate MRG003 - BECOTATUG VEDOTIN - MRG 003 - MRG-003 - MRG003