Spunoleucel

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of off-the-shelf (OTS), donor-derived T-lymphocytes that are specifically reactive towards four community acquired respiratory viruses: respiratory syncytial virus (RSV), influenza, parainfluenza virus (PIV), and human metapneumovirus (hMPV), with potential antiviral activity. Upon infusion into allogeneic hematopoietic stem cell transplant (HSCT), solid organ transplant (SOT) recipients or other immunocompromised patients, spunoleucel provides virus-specific cellular immunity and causes specific anti-viral effects against the four viruses RSV, influenza, PIV and hMPV. This may prevent RSV, influenza, PIV and hMPV infection, and inhibits viral-associated diseases.

**Synonyms:** - ALVR 106 - ALVR-106 - ALVR106 - Allogeneic Multi-VSTs ALVR106 - Allogeneic Multi-virus-specific T-cells ALVR106 - Allogeneic VSTs ALVR106 - SPUNOLEUCEL