Anti-CD1d/Vdelta2 Gamma Delta T-cell Engaging Bispecific Antibody LAVA-051

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized bispecific gamma delta T-cell engager (TCE) antibody directed against both CD1d and Vdelta2, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD1d gamma delta T-cell engaging bispecific antibody LAVA-051 binds to both CD1d-expressing tumor cells and Vgamma9Vdelta2 T-cells. This activates and redirects the Vgamma9Vdelta2 T-cells to CD1d-expressing tumor cells, and the Vgamma9Vdelta2 T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. The Vgamma9Vdelta2 T-cells also activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. In addition, this activates invariant natural killer T-cells (iNKTs). The iNKTs secrete large amounts of various cytokines, which may activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells. CD1d, an antigen-presenting glycoprotein, plays an important role in the presentation of glycolipid antigens to iNKTs; it is also expressed by various hematologic malignancies.

**Synonyms:** - Anti-CD1d/Anti-Vdelta2 Gamma Delta Bispecific T-cell Engager Antibody LAVA-051 - CD1d x Vdelta2 Gamma Delta bsTCE Antibody LAVA-051 - LAVA 051 - LAVA-051 - LAVA051 - bsTCE Antibody LAVA-051