Leukotriene D4

**Semantic type:** Biologically Active Substance|Organic Chemical

**Definition:** A leukotriene synthesized from leukotriene C4 secreted by basophils via removal of a glutamic acid group by cell surface proteases. Leukotriene D4 (LTD4) induces the contraction of smooth muscle cells, which results in bronchoconstriction and vasoconstriction, and increases vascular permeability. LTD4 can be further cleaved by cell surface proteases that remove a glycine group to form leukotriene E4.

**Synonyms:** - (5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-Amino-3-[(Carboxymethyl)Amino]-3-Oxopropyl}Sulfanyl)-5-Hydroxyicosa-7,9,11,14-Tetraenoic Acid - (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-Hydroxybutyl)-2,4,6,9-Pentadecatetraenyl)-L-Cysteinyl)Glycine - 5S-Hydroxy-6R-(S-Cysteinylglycinyl)-7E,9E,11E,14Z-Eicosatetraenoic Acid - Glycine, N-(S-(1-(4-Carboxy-1-Hydroxybutyl)-2,4,6,9-Pentadecatetraenyl)-L-Cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))- - LEUKOTRIENE D4 - LTD4 - S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-Hydroxybutyl]Pentadeca-2,4,6,9-Tetraen-1-Yl}-L-Cysteinylglycine