Activating AKT3 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the AKT3 gene that results in constitutive activation of RAC-gamma serine/threonine-protein kinase and its downstream signaling pathways.

**Synonyms:** - AKT3 Activating Mutation - AKT3 Gain of Function Gene Mutation - AKT3 Gain of Function Mutation - AKT3 Gene Activating Mutation - Activating AKT Serine/Threonine Kinase 3 Gene Mutation - Activating PKB-GAMMA Gene Mutation - Activating PKBG Gene Mutation - Activating PRKBG Gene Mutation - Activating RAC-Gamma Gene Mutation - Activating RAC-PK-Gamma Gene Mutation - Activating STK-2 Gene Mutation - Gain of Function AKT3 Gene Mutation - Gain of Function AKT3 Mutation