Activating AKT2 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the AKT2 gene that results in constitutive activation of RAC-beta serine/threonine-protein kinase and its downstream signaling pathways.

**Synonyms:** - AKT2 Activating Mutation - AKT2 Gain of Function Gene Mutation - AKT2 Gain of Function Mutation - AKT2 Gene Activating Mutation - Activating AKT Serine/Threonine Kinase 2 Gene Mutation - Activating PKBB Gene Mutation - Activating PKBBETA Gene Mutation - Activating PRKBB Gene Mutation - Activating RAC-BETA Gene Mutation - Activating RAC-PK-Beta Gene Mutation - Activating v-akt Murine Thymoma Viral Oncogene Homolog 2 Gene Mutation - Gain of Function AKT2 Gene Mutation - Gain of Function AKT2 Mutation