PDE3A wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PDE3A wild-type allele is located in the vicinity of 12p12.2 and is approximately 320 kb in length. This allele, which encodes cGMP-inhibited 3',5'-cyclic phosphodiesterase A protein, plays a role in the regulation of cAMP- and cGMP-mediated signaling. Mutation of the gene is associated with hypertension and brachydactyly syndrome.

**Synonyms:** - CGI-PDE - CGI-PDE A - CGI-PDE-A - HTNB - Phosphodiesterase 3A wt Allele - Phosphodiesterase 3A, cGMP-Inhibited Gene - cAMP Phosphodiesterase, Myocardial cGMP-Inhibited Gene