HIF2alpha Inhibitor DFF332

**Semantic type:** Pharmacologic Substance

**Definition:** An inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon administration, HIF-2alpha inhibitor DFF332 targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors.

**Synonyms:** - DFF 332 - DFF-332 - DFF332 - HIF-2a Inhibitor DFF332