Topical Keratinocyte Growth Factor Hair Serum

**Semantic type:** Pharmacologic Substance

**Definition:** A topical formulation of keratinocyte growth factor (KGF; fibroblast growth factor 7; FGF-7) with potential use for the prevention and treatment of chemotherapy-induced alopecia. Upon topical administration, topical KGF hair serum acts similarly to endogenous KGF and binds to the KGF receptor. This results in stimulation of proliferation and differentiation of epithelial cells and upregulation of cytoprotective mechanisms, which may prevent and treat chemotherapy-induced alopecia. The KGF receptor is expressed on epithelial cells in the skin, including hair follicles and sebaceous glands, and other tissues; the KGF pathway plays an important role in hair follicle growth and differentiation.

**Synonyms:** - KGF-HS - Keratinocyte Growth Factor Hair Serum - Topical KGF Hair Serum - Topical KGF-HS