Minor Salivary Gland Intraductal Papillary-Mucinous Neoplasm

**Semantic type:** Neoplastic Process

**Definition:** A rare, low-grade epithelial neoplasm with ductal differentiation that grows within and is limited to the duct system of the minor salivary glands. It is characterized by a proliferation of mucin-producing cells within the minor salivary gland ducts, intraductal accumulation of mucin, and a papillary growth pattern. Cytologic and architectural atypia and mitotic activity are present. AKT1 gene mutations have been identified in the majority of cases. Morphologically it resembles the intraductal papillary-mucinous neoplasms of the pancreas.

**Synonyms:** - Minor Salivary Gland IPMN - Minor Salivary Gland Intraductal Papillary Mucinous Neoplasm