Autologous Multiple Antigen-specific T-cells MASE-T

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-cells targeting multiple antigens expressed by melanoma cells, with potential immunomodulating and antineoplastic activities. Peripheral blood T-cells from the patient are collected, processed with artificial antigen-presenting scaffolds, and enriched and expanded ex-vivo to generate multiple antigen-specific endogenously-derived T-cells (MASE-T) targeting multiple antigens expressed by melanoma cells. Upon administration, the autologous multiple antigen-specific T-cells MASE-T are re-introduced into the patient, where they target and kill melanoma cells expressing these specific antigens.

**Synonyms:** - MASE-T - MASE-T Cells - Multiple Antigen Specific Endogenously Derived T Cells - Multiple Antigen-specific Endogenously-derived T-cells