BRD9 Degrader FHD-609

**Semantic type:** Pharmacologic Substance

**Definition:** A protein degrader of bromodomain-containing protein 9 (BRD9; sarcoma antigen NY-SAR-29; rhabdomyosarcoma antigen MU-RMS-40.8), with potential antineoplastic activity. FHD-609 is comprised of an E3 ligase-binding moiety and a BRD9-binding moiety. Upon administration, BRD9 degrader FHD-609 targets and binds to BRD9 with its BRD9-binding moiety. Upon BRD9 binding, the E3 ligase-binding moiety binds to a receptor on the E3 ligase complex which directs proteins for destruction, resulting in the degradation of BRD9. This leads to an inhibition of the growth of tumor cells that rely on BRD9 for survival. BRD9, a component of one form of the Brg/Brahma-Associated Factor (BAF) complex, is needed for the survival of certain cancer cells due to mutations.

**Synonyms:** - BRD9 Protein Degrader FHD-609 - FHD 609 - FHD-609 - FHD609