PKA Regulatory Subunit RIalpha Mixed-Backbone Antisense Oligonucleotide GEM 231

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A mixed backbone oligonucleotide exhibiting antitumor activity. GEM-231 is complementary to the RI alpha subunit of Protein Kinase A (PKA), resulting in downregulation of PKA expression and ultimately tumor growth. (NCI)

**Synonyms:** - GEM 231 - GEM 231 - GEM-231 - GEM231 - Gene Expression Modulator 231