SUPT16H wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SUPT16H wild-type allele is located in the vicinity of 14q11.2 and is approximately 33 kb in length. This allele, which encodes FACT complex subunit SPT16 protein, is involved in chromatin stability, mRNA elongation, DNA replication and DNA repair. Mutation of the gene is associated with neurodevelopmental disorder with dysmorphic facies and thin corpus callosum.

**Synonyms:** - CDC68 - Chromatin-Specific Transcription Elongation Factor, 140-kD Gene - FACT, 140-kD Subunit Gene - FACT140 - FACTP140 - FLJ10857 - FLJ14010 - NEDDFAC - SPT16 - SPT16 Homolog, Facilitates Chromatin Remodeling Subunit wt Allele - SPT16, S. cerevisiae, Homolog of Gene - SPT16/CDC68 - Suppressor of Ty (S.cerevisiae) 16 Homolog Gene - Suppressor of Ty 16 Homolog (S. cerevisiae) Gene - Suppressor of Ty 16 Homolog Gene - Suppressor of Ty 16, S. cerevisiae, Homolog of Gene