GeoMx Digital Spatial Profiler

**Semantic type:** Laboratory Procedure

**Definition:** A method to stain for RNA or protein from tissue sections that combines spatial and molecular profiling technologies by generating a whole tissue image at single cell resolution along with digital profiling data. A tissue section is reacted with up to 4 fluorescent morphology markers and tens to thousands of RNA or protein detection reagents barcoded with unique photocleavable oligonucleotides. The oligonucleotide markers are then imaged from regions of interest to be identified and quantitated.

**Synonyms:** - GeoMx-DSP - GeoMx-DSP