Complement C3 Beta Chain

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Complement C3 beta chain (645 aa, ~71 kDa) is encoded by the human C3 gene. This protein is involved in binding to microbial surfaces, attachment to Fc regions of antigen-bound antibodies, opsonization, phagocytosis and complement activation. Uncontrolled generation of this protein fragment is associated with C3 glomerulopathy and atypical hemolytic uremic syndrome (aHUS).

**Synonyms:** - C3b - Complement C3b - Complement Component C3b