Autologous Anti-CD19 CAR-expressing T-lymphocytes IC19/1563

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes IC19/1563 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies.

**Synonyms:** - Autologous CAR-T Cells IC19/1563 - CD19-directed CAR-T Cells IC19/1563 - IC19 1563 - IC19-1563 - IC19/1563