Trimodulin

**Semantic type:** Pharmacologic Substance

**Definition:** A human plasma-derived polyvalent antibody preparation consisting of human immunoglobulin M (IgM), IgA and IgG, with potential antibacterial, antiviral and immunomodulatory activities. Upon administration of trimodulin, the IgM component may increase the elimination of infectious pathogens including viruses and bacteria in comparison to immunoglobulin regimens lacking IgM. IgM is the major immunoglobulin secreted during the primary immune response and plays a significant role in compliment activation and in the neutralization of bacterial and viral toxins. In addition, the polyvalent antibody preparation may modulate both the pro- and anti-inflammatory processes and prevent the attack of host tissues by the immune system. Low levels of plasma IgG, IgM and IgA has been associated with reduced survival in severe sepsis or septic shock.

**Synonyms:** - BT 588 - BT-588 - BT588