Paridiprubart

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A monoclonal antibody directed against toll-like receptor 4 (TLR4), with potential anti-inflammatory activity. Upon administration, paridiprubart targets TLR4, blocks its receptor dimerization and inhibits TLR4 signaling, thereby inhibiting TLR4-mediated pro-inflammatory cytokine secretion and inflammatory response. This may reduce lung injury in acute respiratory distress syndrome (ARDS). TLR4, a member of the TLR family found on macrophages, dendritic cells (DCs) and other innate immune cells, is an important mediator of cytokine release and inflammatory response in viral infections.

**Synonyms:** - Anti-TLR4 Monoclonal Antibody EB05 - Anti-toll-like Receptor 4 Monoclonal Antibody EB05 - EB 05 - EB-05 - EB05 - NI-0101 - PARIDIPRUBART