Tumor Replication Error Analysis

**Semantic type:** Molecular Biology Research Technique

**Definition:** Certain tumors contain widespread deletions within mono- and dinucleotide repeat sequences in their DNA, referred to as the replication error (RER+) phenotype. The RER+ status of tumors is usually determined by examining several dinucleotide and mononucleotide repeats for size variations when compared with the matching normal DNA.