Semaxanib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.

**Synonyms:** - H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro- - SEMAXANIB - SU 5416 - SU5416 - SU5416 - Semoxind - Sugen 5416 - semaxanib