CD19x22 Bicistronic CAR T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of T-lymphocytes that have that have been transduced with a bicistronic vector encoding two distinct chimeric antigen receptors (CARs), one against the tumor-associated antigen (TAA) CD19 and the other one against the TAA CD22, with potential immunomodulating and antineoplastic activities. Upon administration, the CD19x22 bicistronic CAR T-cells target, bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens using two different CARs, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies.

**Synonyms:** - Anti-CD19/CD22 Bicistronic CAR T-cells - CD19/CD22 Bicistronic CAR-transduced T Cells - CD19x22 Bicistronic CAR T-lymphocytes - CD19xCD22 Bicistronic CAR T-cells