RevM10 Gene

**Semantic type:** Gene or Genome|Pharmacologic Substance

**Definition:** RevM10 is a dominant-negative mutant of HIV-1 Rev gene, which encodes an RNA-binding protein involved in nuclear trafficking of unspliced viral mRNAs. The fact that Rev is essential for HIV-1 replication makes it an attractive target for antiviral approaches. Based on the notion of intracellular immunization, in vitro studies that introduce RevM10 gene into stem cells have demonstrated its ability to combat HIV-1 infection in human hematopoietic cells.

**Synonyms:** - RevM10 gene