Oncogenes, Protein-Kinase

**Semantic type:** Classification

**Definition:** Human Protein-Kinase Oncogenes are mutated variants of Kinase Family Genes, which encode diverse Protein Kinases. Protein kinase enzymes catalyze the conversion of a protein to a phosphoprotein by covalently transferring the terminal, gamma phosphate group from ATP to a variety of substrates that typically play key regulatory roles in diverse cellular functions. Protein-Kinase oncogenes disrupt normal cell function.