Oncogene TIM

**Semantic type:** Gene or Genome

**Definition:** Oncogene TIM encodes a predicted 60 kD protein containing a DBL homology domain, shared by several signal transducing regulators of small GTP-binding proteins. TIM is thought to control cytoskeletal organization through regulation of small GTP-binding proteins. The human gene is located at 7q33-q35.

**Synonyms:** - Guanine nucleotide regulatory protein TIM gene - Rho guanine nucleotide exchange factor 5 gene - Transforming immortalized mammary oncogene