Fluorine F 18 PT2385

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate containing PT2385, a small molecule inhibitor of the hypoxia inducible factor (HIF)-2alpha, conjugated to the positron-emitting isotope fluorine F 18, with potential imaging activity upon positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 PT2385, the PT2385 moiety specifically targets and binds to HIF-2alpha overexpressed on tumor cells, thereby allowing the visualization of tumor cells expressing HIF-2alpha upon PET/CT. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors.

**Synonyms:** - 18F-PT2385 - Fluorine-18 PT2385 - [18F]-PT2385 - [18F]PT2385