Microtubule-Associated Proteins 1A/1B Light Chain 3-I

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Microtubule-associated proteins 1A/1B light chain 3-I (LC3-I) are cytoplasmic products of the autophagy-dependent processing of microtubule-associated proteins 1A/1B light chain 3 family proteins (LC3) by cysteine protease ATG4B. As autophagy progresses LC3-I is further cleaved and processed via the conjugation of a phospholipid anchor to form the membrane localized LC3-II.

**Synonyms:** - LC3 I - LC3-I - MAP1LC3-I