Anti-CD38/CD3 Bispecific Monoclonal Antibody XmAb18968

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific monoclonal antibody targeting CD3, a T-cell surface antigen, and CD38, a human cell surface glycoprotein and tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD3/CD38 bispecific monoclonal antibody XmAb18968 binds to both CD3 on T-cells and CD38 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis.

**Synonyms:** - Anti-CD3/CD38 Bispecific Monoclonal Antibody XmAb18968 - CD3 x CD38 Bispecific Monoclonal Antibody XmAb18968 - XmAb 18968 - XmAb-18968 - XmAb18968