Allogeneic Anti-CD5 CAR T Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for CD5, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD5 CAR T cells target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells and overexpressed on various B- and T-cell malignancies.

**Synonyms:** - Allogeneic Anti-CD5 CAR-T Cells - Allogeneic CD5-targeting CAR T-cells - Donor-derived Anti-CD5 CAR T Cells - Donor-derived CD5 CAR T Cells