Oncogene MYCN

**Semantic type:** Gene or Genome

**Definition:** Human Oncogene NMYC is a mutated variant of NMYC Gene (MYC Family), which encodes two nuclear N-MYC Proteins from the same mRNA; both are phosphorylated, exceptionally unstable and bind to single- and double-stranded DNA. N-MYC is a likely heterodimeric bZIP transcription factor with MAX; efficient DNA binding requires dimerization with another bHLH protein. NMYC amplification is associated with oncogenic transformation. Oncogene NMYC disrupts normal cell function.

**Synonyms:** - N-MYC - Neuroblastoma MYC Oncogene - Oncogene NMYC - v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian)