Oncogene ETS

**Semantic type:** Gene or Genome

**Definition:** Oncogene ETS was originally discovered as a chimeric component, along with a truncated v-myb gene, in the genome of E26, an avian leukosis virus. ETS1 encodes 42-52 kD nuclear phosphoprotein transcription factors that interact with purine-rich promoter/enhancer sequences in the TCRA gene. ETS1 also regulates p16(INK4A) gene expression. The human gene is located at 11q23.3.

**Synonyms:** - E26 Transformation Specific Oncogene - ETS